您可以使用为您反转布尔属性的ValueConverter。

XAML：

IsEnabled="{Binding Path=IsReadOnly, Converter={StaticResource InverseBooleanConverter}}"

转换器：

[ValueConversion(typeof(bool), typeof(bool))]
    public class InverseBooleanConverter: IValueConverter
        #region IValueConverter Members
        public object Convert(object value, Type targetType, object parameter,
            System.Globalization.CultureInfo culture)
            if (targetType != typeof(bool))
                throw new InvalidOperationException("The target must be a boolean");
            return !(bool)value;
        public object ConvertBack(object value, Type targetType, object parameter,
            System.Globalization.CultureInfo culture)