研究内容：
本实验室研究方向聚焦肿瘤的精准诊断和精准免疫治疗。恶性肿瘤本质上是由体细胞
DNA
变异驱动的系统疾病，本实验室方向是从基因组
DNA
变异角度系统研究肿瘤发生以及演化的规律，寻找预测肿瘤临床表现的标志物，并设计针对性的治疗策略，尤其是针对性的免疫治疗策略。目前实验室的具体研究内容包括：
1
，肿瘤基因组
DNA
拷贝数变异特征模式分析、机制研究，以及“拷贝数指纹”标志物的优化与应用。
结合基因组分析、人工智能与体外细胞实验，研究拷贝数变异的特征模式，产生机制。开发便捷的拷贝数指纹实验检测手段，并在肿瘤早筛、监测、免疫治疗以及靶向治疗临床标志物开发中的推广应用。
2
，肿瘤基因组
DNA
变异编码的免疫原性分析以及生成式
AI
驱动的肿瘤精准免疫治疗。
利用人工智能大数据分析技术，结合细胞以及小鼠模型实验，深入研究抗原肽
/MHC/TCR
三元体互作的机制，实现高效新抗原疫苗设计、新抗原靶向
TCR
生成验证与应用，并转化于肿瘤病人的精准免疫治疗实践。
3
，开发多模态组学整合可解释性
AI
方法，研发肿瘤精准分子分型策略以及精准治疗靶点。
关注难治肿瘤（如粘液腺癌、黏膜恶黑等）的精准分子分型，为难治性肿瘤提供有效的直接指导临床的分型策略。关注肿瘤代谢靶点的发掘，探究代谢对肿瘤免疫治疗有效性的影响。
课题组网站：
近
5
年来本实验室在肿瘤基因组大数据分析以及肿瘤精准诊疗方向取得一系列原创的、具有临床应用前景的重要发现。结合基因组人工智能（
AI
）分析检测，提出全新的“拷贝数指纹”标志物，大幅提升了癌症复发预测、化疗及免疫治疗诊断预测的精度，同时降低了检测成本。创新地开发了“肿瘤免疫原性指数”标志物，利用
AI
开发出肿瘤新抗原免疫原性预测工具。利用
AI
首次实现对肿瘤代谢依赖性靶点的系统发掘并实验验证，发现肿瘤缺氧适应的新靶点
FLAD1
并开发首个
FLAD1
抑制剂。实验室的研究工作紧密联系肿瘤临床的实际痛点问题，以第一负责人申报国家发明专利
10
项（已授权
8
项），部分专利的产业化工作正在稳步推进中。实验室负责人编著有国内第一本《癌症生物学》教科书（上海科学技术出版社，约
60
万字）。近
5
年在知名学术期刊（如
Cancer Res, eLife
，
Brief Bioinform
，
Oncogene
）发表唯一通讯作者研究论文超过
20
篇，多篇通讯作者研究论文被
ESI
标记为“高被引论文”，连续入选
2022
、
2023
年度
Elsevier
发布的“中国高被引学者”榜单。
《癌症生物学》刘雪松编著，上海科学技术出版社，2024年出版
3.
Ning, Wei*; Wu, Tao; Wu, Chenxu; Wang, Shixiang; Tao, Ziyu; Wang, Guangshuai; Zhao, Xiangyu; Diao, Kaixuan; Wang, Jinyu; Chen, Jing; Chen, Fuxiang; Liu, Xue-Song
#
; .
Accurate prediction of pan-cancer types using machine learning with minimal number of DNA methylation sites.
JOURNAL OF MOLECULAR CELL BIOLOGY
. Apr 2023.
7.
Diao, Kaixuan*; Chen, Jing; Wu, Tao; Wang, Xuan; Wang, Guangshuai; Sun, Xiaoqin; Zhao, Xiangyu; Wu, Chenxu; Wang, Jinyu; Yao, Huizi; Gerarduzzi, Casimiro; Liu, Xue-Song
#
; .
Seq2Neo: A Comprehensive Pipeline for Cancer Neoantigen Immunogenicity Prediction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
. Oct 2022. 23(19).
9.
Jianfeng Li
#
*; Benben Miao*; Shixiang Wang*; Wei Dong*; Houshi Xu*; Chenchen Si*; Wei Wang; Songqi Duan; Jiacheng Lou; Zhiwei Bao; Hailuan Zeng; Zengzeng Yang; Wenyan Cheng; Fei Zhao; Jianming Zeng; Xue-Song Liu
#
; Renxie Wu
#
; Yang Shen
#
; Zhu Chen
#
; Saijuan Chen
#
; Mingjie Wang
#
; .
Hiplot: a comprehensive and easy-to-use web service for boosting publication-ready biomedical data visualization.
BRIEFINGS IN BIOINFORMATICS
. Jul 2022.
11.
He, Zaoke*; Sun, Xiaoqin; Wang, Shixiang; Bai, Dongsheng; Zhao, Xiangyu; Han, Ying; Hao, Piliang; Liu, Xue-Song
#
; .
Ggct (g-glutamyl cyclotransferase) plays an important role in erythrocyte antioxidant defense and red blood cell survival.
BRITISH JOURNAL OF HAEMATOLOGY
. Oct 2021. 195(2):267-275.
23.
Chen, Ming*; Zhang, Jiangwen; Sampieri, Katia; Clohessy, John G.; Mendez, Lourdes; Gonzalez-Billalabeitia, Enrique; Liu, Xue-Song; Lee, Yu-Ru; Fung, Jacqueline; Katon, Jesse M.; Menon, Archita Venugopal; Webster, Kaitlyn A.; Ng, Christopher; Palumbieri, Maria Dilia; Diolombi, Moussa S.; Breitkopf, Susanne B.; Teruya-Feldstein, Julie; Signoretti, Sabina; Bronson, Roderick T.; Asara, John M.; Castillo-Martin, Mireia; Cordon-Cardo, Carlos; Pandolfi, Pier Paolo
#
; .
An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer.
NATURE GENETICS
. 2018. 50(2):206+.
24.
Gerarduzzi, Casimiro*; de Polo, Anna; Liu, Xue-Song; El Kharbili, Manale; Little, John B.; Yuan, Zhi-Min
#
; .
Human epidermal growth factor receptor 4 (Her4) Suppresses p53 Protein via Targeting the MDMX-MDM2 Protein Complex IMPLICATION OF A NOVEL MDMX SER-314 PHOSPHOSITE.
JOURNAL OF BIOLOGICAL CHEMISTRY
. 2016. 291(50):25937-25949.
26.
Liu, Xue-Song*; Chandramouly, Gurushankar; Rass, Emilie; Guan, Yinghua; Wang, Guocan; Hobbs, Robin M.; Rajendran, Anbazhagan; Xie, Anyong; Shah, Jagesh V.; Davis, Anthony J.; Scully, Ralph
#
; Lunardi, Andrea
#
*; Pandolfi, Pier Paolo
#
; .
LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair.
NATURE COMMUNICATIONS
. 2015. 6.
27.
Liu, Xue-Song*; Genet, Matthew D.; Haines, Jenna E.; Mehanna, Elie K.; Wu, Shaowei; Chen, Hung-I Harry; Chen, Yidong; Qureshi, Abrar A.; Han, Jiali; Chen, Xiang; Fisher, David E.; Pandolfi, Pier Paolo; Yuan, Zhi-Min
#
; .
ZBTB7A Suppresses Melanoma Metastasis by Transcriptionally Repressing MCAM.
MOLECULAR CANCER RESEARCH
. 2015. 13(8):1206-1217.
29.
Gonzalez-Billalabeitia, Enrique*; Seitzer, Nina; Song, Su Jung; Song, Min Sup; Patnaik, Akash; Liu, Xue-Song; Epping, Mirjam T.; Papa, Antonella; Hobbs, Robin M.; Chen, Ming; Lunardi, Andrea; Ng, Christopher; Webster, Kaitlyn A.; Signoretti, Sabina; Loda, Massimo; Asara, John M.; Nardella, Caterina; Clohessy, John G.; Cantley, Lewis C.; Pandolfi, Pier Paolo
#
; .
Vulnerabilities of PTEN-TP53-Deficient Prostate Cancers to Compound PARP-PI3K Inhibition.
CANCER DISCOVERY
. 2014. 4(8):896-904.
31.
Wang, Guocan*; Lunardi, Andrea; Zhang, Jiangwen; Chen, Zhenbang; Ala, Ugo; Webster, Kaitlyn A.; Tay, Yvonne; Gonzalez-Billalabeitia, Enrique; Egia, Ainara; Shaffer, David R.; Carver, Brett; Liu, Xue-Song; Taulli, Riccardo; Kuo, Winston Patrick; Nardella, Caterina; Signoretti, Sabina; Cordon-Cardo, Carlos; Gerald, William L.; Pandolfi, Pier Paolo
#
; .
Zbtb7a suppresses prostate cancer through repression of a Sox9-dependent pathway for cellular senescence bypass and tumor invasion.
NATURE GENETICS
. 2013. 45(7):739+.
32.
Zhang, Hong-Xin*; Liu, Zi-Xing; Sun, Yue-Ping; Zhu, Jiang; Lu, Shun-Yuan; Liu, Xue-Song; Huang, Qiu-Hua; Xie, Yin-Yin; Zhu, Hou-Bao; Dang, Su-Ying; Chen, Hai-Feng; Zheng, Guang-Yong; Li, Yi-Xue; Kuang, Ying; Fei, Jian; Chen, Sai-Juan; Chen, Zhu
#
; Wang, Zhu-Gang
#
; .
Rig-I regulates NF-kappa B activity through binding to Nf-kappa b1 3 '-UTR mRNA.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
. 2013. 110(16):6459-6464.
33.
Xue-Song Liu*; Xu-Dong Zhao*; Xiaoxing Wang*; Yi-Xin Yao; Liang-Liang Zhang; Run-Zhe Shu; Wei-Hua Ren; Ying Huang; Lei Huang; Ming-Min Gu; Ying Kuang; Long Wang; Shun-Yuan Lu; Jun Chi; Jing-Sheng Fen; Yi-Fei Wang; Jian Fei; Wei Dai
#
; Zhu-Gang Wang
#
; .
Germinal Cell Aplasia in Kif18a Mutant Male Mice Due to Impaired Chromosome Congression and Dysregulated BubR1 and CENP-E.
GENES CANCER
. Jan 2010. 1(1):26-39.
34.
Shu, Run-Zhe
#
*; Zhang, Feng; Liu, Xue-Song; Li, Chun-Liang; Wang, Long; Tai, Yi-Lin; Wu, Xiao-Lin; Yang, Xue; Liao, Xiao-Dong; Jin, Ying; Gu, Ming-Min; Huang, Lei; Pang, Xiao-Fen
#
; Wang, Zhu-Gang
#
; .
Target Deletion of the Cytoskeleton-Associated Protein Palladin Does Not Impair Neurite Outgrowth in Mice.
PLOS ONE
. 2009. 4(9).
35.
Wu, Xiao-lin*; Gu, Ming-min; Huang, Lei; Liu, Xue-song; Zhang, Hong-xin; Ding, Xiao-yi; Xu, Jian-qing; Cui, Bin; Wang, Long; Lu, Shun-yuan; Chen, Xiao-yi; Zhang, Hai-guo; Huang, Wei; Yuan, Wen-tao; Yang, Jiang-ming; Gu, Qun; Fei, Jian; Chen, Zhu; Yuan, Zhi-min; Wang, Zhu-gang
#
; .
Multiple Synostoses Syndrome Is Due to a Missense Mutation in Exon 2 of FGF9 Gene.
AMERICAN JOURNAL OF HUMAN GENETICS
. 2009. 85(1):53-63.
36.
Wang, Yi*; Zhang, Hong-Xin; Sun, Yue-Ping; Liu, Zi-Xing; Liu, Xue-Song; Wang, Long; Lu, Shun-Yuan; Kong, Hui; Liu, Qiao-Ling; Li, Xi-Hua; Lu, Zhen-Yu; Chen, Sai-Juan; Chen, Zhu; Bao, Shi-San; Dai, Wei; Wang, Zhu-Gang
#
; .
Rig-I-/- mice develop colitis associated with downregulation of G alpha i2.
CELL RESEARCH
. 2007. 17(10):858-868.
37.
Liu, Xue-Song*; Luo, Hui-Jun; Yang, Hua; Wang, Long; Kong, Hui; Jin, Yue-E; Wang, Fang; Gu, Ming-Min; Chen, Zhu; Lu, Zhen-Yu; Wang, Zhu-Gang
#
; .
Palladin regulates cell and extracellular matrix interaction through maintaining normal actin cytoskeleton architecture and stabilizing beta1-integrin.
JOURNAL OF CELLULAR BIOCHEMISTRY
. 2007. 100(5):1288-1300.
38.
Liu, Xue-Song*; Li, Xi-Hua; Wang, Yi; Shu, Run-Zhe; Wang, Long; Lu, Shun-Yuan; Kong, Hui; Jin, Yue-E; Zhang, Li-Jun; Fei, Jian; Chen, Sai-Juan; Chen, Zhu; Gu, Ming-Min; Lu, Zhen-Yu; Wang, Zhu-Gang
#
; .
Disruption of palladin leads to defects in definitive erythropoiesis by interfering with erythroblastic island formation in mouse fetal liver.
BLOOD
. 2007. 110(3):870-876.
地址：上海市浦东新区华夏中路393号 邮编：201210; 上海市徐汇区岳阳路319号8号楼 邮编：200031（岳阳路校区）
沪公网安备 31011502006855号
Yueyang Campus: 319 Yueyang Road, Shanghai 200031; Zhangjiang Campus: 393 Middle Huaxia Road, Pudong, Shanghai, 201210
沪公网安备 31011502006855号
