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Diabetes mellitus is associated with sexual dysfunction, which leads to infertility in animal models. The aim of this study was to evaluate sexual behavior in diabetic rats administered with naringenin. Rats were classified into five groups including healthy controls, those with STZ‐induced diabetes, and those with STZ‐induced diabetes then treated with 25, 50, or 100 mg kg −1 day −1 of naringenin. Male rats were introduced to sexually receptive females, and data were collected regarding sexual behavior and erectile activity. Blood samples were taken and histopathological analyses were carried out. ANOVA and the Student–Newman–Keuls t test were used for statistical comparisons. Sexual behavioral, mount latency, intromission latency, ejaculation latency, and postejaculatory interval were significantly increased in diabetic rates compared with controls ( p < 0.001). The NG‐treated rats showed a significant improvement in testosterone and cyclic guanosine monophosphate levels, and testicular oxidative stress and inflammatory biomarkers were corrected in a dose‐dependent manner compared with controls. The treatment protocol used in this study led to the elimination of sexual impairment resulting from DM, and naringenin showed significant antiinflammatory and antioxidant effects in testicular cells. 中文翻译: 糖尿病与性功能障碍有关,导致动物模型的不育。这项研究的目的是评估服用柚皮苷的糖尿病大鼠的性行为。将大鼠分为五组,包括健康对照,那些具有STZ诱导的糖尿病,和那些具有STZ诱导的糖尿病,然后用25处理的,50或100mg千克 -1 -1 柚皮素。将雄性大鼠引入性接受雌性的大鼠,并收集有关性行为和勃起活动的数据。采集血样并进行组织病理学分析。方差分析和Student–Newman–Keuls t 检验用于统计学比较。与对照组相比,糖尿病患者的性行为,坐骑潜伏期,性交潜伏期,射精潜伏期和射精后间隔时间明显增加( p <0.001)。NG处理的大鼠睾丸激素和环状鸟苷单磷酸水平显着提高,与对照组相比,睾丸氧化应激和炎症生物标志物的剂量依赖性得以纠正。本研究中使用的治疗方案可消除由DM引起的性功能障碍,柚皮苷对睾丸细胞具有显着的抗炎和抗氧化作用。